Experimental Trial on Ginger Plus Lemon Shots
Trial on Ginger Plus Lemon Shots
DOI:
https://doi.org/10.54393/df.v6i2.189Keywords:
Acne Vulgaris, Ginger, Lemon, Anti-inflammatory, Antioxidants, Natural RemediesAbstract
Acne vulgaris is a widespread skin disease that is affected by several factors, such as inflammation, hormonal status, and dietary factors. Natural products like ginger and lemon, which contain anti-inflammatory and antioxidant phytochemicals, have been potential in controlling symptoms of acne. Objectives: To examine the impact of the ginger plus lemon shot intervention on the severity of acne and associated hematological parameters in young adult women. Methods: This interventional study included 100 female volunteers between 21–24 years of age with mild to moderate acne who were included in a 10-day interventional trial. All volunteers took 100 mL each of fresh ginger and lemon shots once a day. Clinical evaluation by the Global Acne Grading System (GAGS), complete blood count (CBC), and sensory questionnaires were performed before and after the intervention. Dietary consumption and compliance were observed during the study. Results: The intervention significantly decreased acne lesions and redness of the skin, backed by hematological improvement. Reduction in white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels reflected a reduction in systemic inflammation. Sensory evaluation revealed excellent acceptability with scores higher than 4 on a 5-point hedonic scale for taste, aroma, color, and overall acceptability. Conclusions: Intake of ginger along with lemon shots on a daily basis for 10 days showed favorable results in alleviating acne symptoms and systemic inflammation markers without any side effects.
References
1. Żmuda B, Żuberek M, Ślusarczyk D, Pisera P, Kiełkowicz A, Popińska Z, Pactwa F, Jakubowska W. Acne Vulgaris-Review on Pathogenesis and Treatment. Journal of Education, Health and Sport. 2024 Jan; 51: 50-63. doi: 10.12775/JEHS.2024.51.004. DOI: https://doi.org/10.12775/JEHS.2024.51.004
2. Cong TX, Hao D, Wen X, Li XH, He G, Jiang X. From Pathogenesis of Acne Vulgaris to Anti-Acne Agents. Archives of Dermatological Research. 2019 Jul; 311(5): 337-49. doi: 10.1007/s00403-019-01908-x. DOI: https://doi.org/10.1007/s00403-019-01908-x
3. Kolli SS, Pecone D, Pona A, Cline A, Feldman SR. Topical Retinoids in Acne Vulgaris: A Systematic Review. American Journal of Clinical Dermatology. 2019 Jun; 20(3): 345-65. doi: 10.1007/s40257-019-00423-z. DOI: https://doi.org/10.1007/s40257-019-00423-z
4. Cristani M, Micale N. Bioactive Compounds from Medicinal Plants as Potential Adjuvants in the Treatment of Mild Acne Vulgaris. Molecules. 2024 May; 29(10): 2394. doi: 10.3390/molecules29102394. DOI: https://doi.org/10.3390/molecules29102394
5. MS K, MR A. Ginger Revitalized: Exploring the Modern Applications of Zingiber Officinale in Medicine and Beyond. New Armenian Medical Journal. 2024 Sep; 18(3).
6. Dreno B, Gollnick HP, Kang S, Thiboutot D, Bettoli V, Torres V et al. Global Alliance to Improve Outcomes in Acne. Understanding Innate Immunity and Inflammation in Acne: Implications for Management. Journal of the European Academy of Dermatology and Venereology. 2015 Jun; 29: 3-11. doi: 10.1111/jdv.13190. DOI: https://doi.org/10.1111/jdv.13190
7. Magalhães D, Vilas-Boas AA, Teixeira P, Pintado M. Functional Ingredients and Additives from Lemon By-Products and Their Applications in Food Preservation: A Review. Foods. 2023 Mar; 12(5): 1095. doi: 10.3390/foods12051095. DOI: https://doi.org/10.3390/foods12051095
8. Shaukat MN, Nazir A, Fallico B. Ginger Bioactives: A Comprehensive Review of Health Benefits and Potential Food Applications. Antioxidants. 2023 Nov; 12(11): 2015. doi: 10.3390/antiox12112015.
9. Na Nongkhai T, Maddocks SE, Phosri S, Sangthong S, Pintathong P, Chaiwut P, Chandarajoti K, Nahar L, Sarker SD, Theansungnoen T. In Vitro Cytotoxicity and Antimicrobial Activity against Acne-Causing Bacteria and Phytochemical Analysis of Galangal (Alpinia Galanga) and Bitter Ginger (Zingiber Zerumbet) Extracts. International Journal of Molecular Sciences. 2024 Oct; 25(20): 10869. doi: 10.3390/ijms252010869. DOI: https://doi.org/10.3390/ijms252010869
10. Ahmed ME. The Study of Bacteriocin of Pseudomonas Fluorescens and Citrus Limon Effects against Propionibacterium Acnes and Staphylococcus Epidermidis in Acne Patients. Journal of Physics: Conference Series. 2018 May; 1003(1): 012004. doi: 10.1088/1742-6596/1003/1/012004. DOI: https://doi.org/10.1088/1742-6596/1003/1/012004
11. Delves PJ, Roitt IM. The Immune System. New England Journal of Medicine. 2000 Jul; 343(2): 108-17. doi: 10.1056/NEJM200007133430207. DOI: https://doi.org/10.1056/NEJM200007133430207
12. Gupta J, Sharma B, Sorout R, Singh RG, Sharma MC. Ginger (Zingiber Officinale) in Traditional Chinese Medicine: A Comprehensive Review of Its Anti-Inflammatory Properties and Clinical Applications.
13. Pharmacological Research-Modern Chinese Medicine. 2025 Mar; doi: 10.1016/j.prmcm.2024.100561. DOI: https://doi.org/10.1016/j.prmcm.2024.100561
14. Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. International Journal of Preventive Medicine. 2013 Apr; 4(Suppl 1): S36.
15. Ayustaningwarno F, Anjani G, Ayu AM, Fogliano V. A Critical Review of Ginger's (Zingiber Officinale) Antioxidant, Anti-Inflammatory, and Immunomodulatory Activities. Frontiers in Nutrition 2024 Jun; 11: 1364836. doi: 10.3389/fnut.2024.1364836 DOI: https://doi.org/10.3389/fnut.2024.1364836
16. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The Effect of Ginger (Zingiber Officinale) on Glycemic Markers in Patients with Type 2 Diabetes. Journal of Complementary and Integrative Medicine. 2015 Jun; 12(2): 165-70. doi: 10.1515/jcim-2014-0021. DOI: https://doi.org/10.1515/jcim-2014-0021
17. Taofiq O, Barreiro MF, Ferreira IC. The Role of Bioactive Compounds and Other Metabolites from Mushrooms against Skin Disorders-A Systematic Review Assessing Their Cosmeceutical and Nutricosmetic Outcomes. Current Medicinal Chemistry. 2020 Dec; 27(41): 6926-65. doi: 10.2174/0929867327666200402100157. DOI: https://doi.org/10.2174/0929867327666200402100157
18. Mohd Sahardi NF, Makpol S. Ginger (Zingiber Officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence. Evidence-Based Complementary and Alternative Medicine. 2019; 2019(1): 5054395. doi: 10.1155/2019/5054395. DOI: https://doi.org/10.1155/2019/5054395
19. Eichenfield DZ, Sprague J, Eichenfield LF. Management of Acne Vulgaris: A Review. Journal of the American Medical Association. 2021 Nov; 326(20): 2055-67. doi: 10.1001/jama.2021.17633. DOI: https://doi.org/10.1001/jama.2021.17633
20. Dini I, Laneri S. The New Challenge of Green Cosmetics: Natural Food Ingredients for Cosmetic Formulations. Molecules. 2021 Jun; 26(13): 3921. doi: 10.3390/molecules26133921. DOI: https://doi.org/10.3390/molecules26133921
21. Margari L, Gabellone A, Marzulli L, Matera E, Petruzzelli MG. Psychodermatology: When Psyche and Skin Interact. Psychocutaneous Diseases: A Clinical Dermatological Approach. 2024 Nov; 1-4. doi: 10.1007/978-3-031-70296-9_1. DOI: https://doi.org/10.1007/978-3-031-70296-9_1
Downloads
Published
Issue
Section
License
Copyright (c) 2025 DIET FACTOR (Journal of Nutritional and Food Sciences)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments
